Non tutte le ciambelle escono col buco

Let's look at the main, individual words in this expression. 

Ciambella: Una ciambella is often a donut or doughnut. But actually, it can refer to anything that is ring-shaped with a hole in the middle. It can be an "inner tube" you use in the pool, or a life-preserver. Un ciambellone is a large-size coffee cake, usually in the shape of a ring, with a hole in the middle. For more about turning a feminine noun like la ciambella into a big, masculine version such as il ciambellone using the ending -one, see this lesson.

Bona 'sta [buona questa] ciambella.

Good, this doughnut.

Caption 44, Un medico in famiglia Stagione 1 EP1 - Casa nuova - Part 10

 Play Caption

banner PLACEHOLDER

Escono: This is the third person plural of the verb uscire (to exit, to come/go out). In this case, we are talking about a donut or ring-shaped cake coming out of the oven or deep-frier. Sometimes there's a mistake, and one might not have its hole in the middle, it might be lopsided. 

Buco: Un buco is a hole. Just like in the middle of a donut.

Cominciamo a piantarne uno. Allora bisogna fare un buco.

Let's start planting one. So we need to make a hole.

Captions 46-47, Gatto Mirò EP 10 Piantiamo un albero

 Play Caption

A word about the other words:

Non is a negating word, like "not."

Tutte means "all." In this case, it refers to the plural feminine noun, le ciambelle, so it has a plural feminine ending. 
We have the conjunction col. This is a combination of con (with) and il (the).

A variation on this expression is: Non tutte le ciambelle riescono col buco.

The verb changes from uscire to riuscire. While riuscire can mean "to come/go out again," as in when you come home but have to go out again because you forgot to buy milk, it also means "to succeed," "to turn out," "to manage to do something."

Però, non tutti riescono a farlo bene.

However, not everyone succeeds in doing it well.

Caption 10, Anna e Marika Il pane

 Play Caption

So the meaning of the two variants is essentially the same, but with escono, we can visualize the donut coming out of the oven, and with riescono, we can visualize how they turn out.

Yet another variation is: Non tutte le ciambelle vengono col buco. Here the verb is venire (to come). "Not all donuts come with holes." The concept doesn't change.

Literally, the sentence means: "Not all donuts come out [of the oven] with holes." The figurative meaning of the expression is that not everything goes according to plan. Sometimes things turn out imperfectly, but it's not a huge deal. A nuance is that the donut will still taste good even if it is a bit misshapen or lopsided. 

When you or someone else does a job that didn't come out perfectly, it's also a way of minimizing the error, as if to say, "Oh well..."

banner PLACEHOLDER

The Italian verb for “to give” is dare. But if you want to give someone a gift, you need to get used to using the verb fare (to make)—fare un regalo:  

Quella gli faceva un regalino, quell'altra l'invitava a cena...

One would give him a little gift, another would invite him to dinner...

Caption 49, Il Commissario Manara - S1EP3 - Rapsodia in Blu

 Play Caption

Or you can use the verb form of regalo, regalare:

Eh, ma mi sa che questo è l'ultimo anno

Uh, I guess this is the last year

che ti posso regalare le mie scarpe.

that I can give you my shoes.

Caption 4, Un medico in famiglia Stagione 1 - EP1 - Casa nuova

 Play Caption

BANNER PLACEHOLDER

Regalo is analogous with “present,” and it’s the word you will be using most of the time. However, another way to say “gift,” which often implies a divine or important giver, is dono. You’ll hear it in conjunction with traditions, and indeed, dono is used like regalo in talking about what Santa Claus brings down the chimney.

Ovviamente ai bambini portava doni.

Obviously to children he brought gifts.

Caption 16, Marika spiega - La vera storia di Babbo Natale

 Play Caption

Donare is easy to remember, being very similar to “donate.” In fact, as a verb, donare can mean “to donate,” as in money or blood: donare sangue (to give blood). Blood donors are donatori di sangue.

Of course, gifts are not always tangible.

Perché io lavoro con un grande dono prezioso che ognuno di noi ha...

Because I work with a precious gift that each one of us has...

Io lavoro con la mia voce.

I work with my voice.

Captions 7-9, Marika e Daniela - Daniela Bruni, voice over

 Play Caption

And now you need to stretch your mind a bit because the giver is an item of clothing. The shirt in question gives the wearer some positive quality. This particular use of donare is worth remembering because it’s a wonderful way to compliment someone! (Note that the person is using the polite form; to a friend you would say ti dona.)

Ah... ma lo sa che questa camicia le dona?

Ah... you know that this shirt looks good on you?

-Grazie. -Sì. Fa esaltare il colore dei suoi occhi.

-Thanks. -Yes. It brings out the color of your eyes.

Captions 8-9, Il Commissario Manara - S1EP2 - Vendemmia tardiva

 Play Caption

Finally we have dote (talent, gift, quality) with its verb form, dotare. Except for when it means “endowment” or “dowry,” dote isn’t the kind of gift you can give someone. 

Il ragazzo è dotato per la musica e sua sorella invece è dotata per il disegno.

The boy is a gifted musician while his sister is a gifted artist.

Ha una dote per la musica.

He has a gift for music.  

We could say that God, or some higher being has “provided” that boy with his gift for music. So don’t be surprised if you go to buy a TV in Italy and the salesman tells you that la TV è dotata di telecommando (the TV is supplied with remote control). Not God-given, but factory-given!

To sum up on a practical level (leaving Christmas, weddings, and TVs aside):

• Il Regalo and regalare have to do with worldly things for the most part, things one person can give another. Regalo can be synonymous with “present.” Remember to use the verb fare with regalo! 
• La dote and dotare have more to do with talent, and you can’t give someone this kind of gift.
• Il dono and donare mostly give the idea of a bigger picture: a gift from God, a donation to a cause, donating blood or organs. But donare can also mean “to enhance,” to bring out positive qualities.

BANNER PLACEHOLDER

Learning suggestion:

What are your natural talents or gifts? What about those of your family and friends? What did you get for a present on your last birthday? Do you know people who give blood? What are the earth’s natural gifts? Make a list of what comes to mind and then choose the Italian word that is closest in meaning.

To test out any phrases you come up with, just Google them and you will probably get some clues. If you have doubts, use WordReference or other dictionaries to get some more complete input than this lesson can provide.