It's the first day of school for our friends. In fact, it's their first year of middle school. The desks are set up for pairs of pupils, so choices have to be made as to where to sit and whom to share a desk with.

It's breakfast time in the Martini household. Lele is late but he has to deal with Alberto. Cettina and Libero have a little discussion about pillows and work.

Nilde calls her brother, Lele, wondering if Alberto had shown up there. The next-door neighbors come by with some information, but they bicker so much that it is hard for Lele and Libero to figure out what they are talking about. But somehow, Lele finally puts two and two together.

Alice introduces us to her group of friends. They've called themselves "JAMS" and we find out why in this episode. She begins telling us the story of how they got to know one another. Alice talks about la prima media. This is equivalent to the first year of middle school or the 6th grade of elementary school. The kids are about 11 or 12 years old.

Cettina is complaining about all the work she has to do and Lele is trying to come up with a plan so that family members can help out. Ciccio is trying to get something to eat for Alberto, who is in hiding.

Libero goes to the job interview, where his future employer throws around some words in English that Libero has no idea about. He is shown a product with a demonstration of some of its features.

It's the night before Luigi's operation. It's hard to sleep for various reasons, but he is resting, when Doctor Zamagna pays him a visit.

Lele deals with a patient who says she has trouble sleeping. Libero answers an ad from a sleep center.

Luigi's wife reads the consent form. Meanwhile, Luigi gets prepped by different nurses for the operation he will have the next day.

Lele is trying to get Annuccia to eat her lunch and Libero helps out. Uncle Giulio stops by to tell Lele he should get out more and start dating.

Doctor Policari brings the consent form, along with some seemingly paradoxical advice. Luigi's wife tries to get more information from this doctor, without success.

Ciccio and Maria are in the backyard, when Alberto shows up unexpectedly. The neighbors look on.

Some patients are afraid to go home, to do things for themselves, but once they are well, they must. Luigi waits to sign the informed consent form before his operation. He hears about Doctor Zamagna who will be performing the surgery.

The whole family goes to the opening of Nilde's restaurant, and there are a few surprises.

Luigi discovers that not only is his oncologist young, but he is his first patient. Luigi and his wife are nervous but ready, while the department head seems to be more interested in her phone call.