Lojacono pursues and arrests Donato Cuocolo. After attempting to flee and threatening the officers with a brick, he is stopped by Alex Di Nardo. At the police station, the investigators put him under pressure: he risks many years in prison, but he can face a lighter charge if he cooperates.

Marioni is forced to give up conducting the concert due to his injury, while Rosario receives an affectionate visit from his mother, between tenderness and a touch of embarrassment. In a record shop, unexpected confidences emerge and, once again, between music and complicity, the young people confront love and friendship.

In this part Fabiola Gianotti talks about the connection between science and creativity, combining physics and music as universal forms of expression. She also explains the work of the Large Hadron Collider, where proton beams are made to collide to study the universe right after the Big Bang.

Camilla finds herself involved in the difficult situation of one of her former students, obsessed with Quantunque, who has mysteriously disappeared and whom she wants to help at any cost. Between enigmatic messages and a photograph that has resurfaced from the past, the investigations proceed amid suspicions and uncertainties, without yet a real breakthrough.

While Romano talks with the doctor, he meets Giorgia at the hospital, who is there to assist her hospitalized mother. Meanwhile, at the police station, new clues emerge about a suspect linked to a criminal clan, while Laura and Giuseppe share moments of complicity that lighten the tension of the investigation.

In this moment of confrontation, Irene and Luca face the consequences of what happened, while within the group of students tension grows between some of them. Between misunderstandings, sense of responsibility and need for closeness, emotional conflicts and fragments of daily life alternate.

Matteo tells us how fundamental it is to know the entire score, not just one's own part, in order to best interpret a piece. For him, music is above all education in listening: to the composer, to other musicians, and to oneself. Playing together thus becomes an experience of growth and mutual care, even before it becomes artistic.

The physicists describe their amazement at the grandeur of the detector, a symbol of collective scientific effort that unites different cultures to understand the universe. A work compared to a cathedral, an expression of science as part of civilization's progress.

Gaetano notices that Camilla is more serene and she confides in him that Renzo, too, finally seems to have calmed down. However, the peace is shattered when Ventruti reaches the commissioner to get confirmation about the identity of the woman found dead. Devastated, the man lets all his pain emerge and reveals details that could prove crucial for the investigation.

A mysterious phone call casts Lojacono into shadow: a stranger from Agrigento hints at an unpaid mortgage and lets slip a veiled threat.
Meanwhile, Romano focuses all his anguish on little Giorgia. Between fear and hope, the doctors try to reassure him about the child's condition.

A song about pain and heartbreak serves as background to the students who receive news of maestro Marioni's absence, due to a minor accident. The suspension of orchestra rehearsals generates different reactions among the young people, between relief, expectations for an upcoming concert and reflections on shared work.

Sometimes the accompanist has to follow the soloist's musical intentions, but at other times, when the musician is not very experienced, the accompanist needs to guide the soloist and make the best of a potentially tricky musical situation. This depends on the musical and technical level of the soloist, as well as the experience and maturity of the accompanist.

Fabiola and her colleagues retrace the long journey toward the discovery of the Higgs boson: from Peter Higgs' theoretical intuition to the difficult meetings at CERN, up to the realization of the Large Hadron Collider, initially considered almost impossible.

Anna and Camilla enter Quantunque's apartment to understand why he hasn't been to the restaurant anymore; the only suspicious element is a suitcase locked with a combination. Meanwhile, at home, Renzo appears more serene after talking with his mother-in-law and attempts a reconciliation by preparing dinner.

Rosaria appears very impressed by Alex's new house and, between one compliment and another, updates her partner on the latest developments in the investigation. Meanwhile Lojacono goes to the restaurant to see Letizia, who welcomes him by offering a rich and inviting selection of typical Neapolitan dishes.