Caravaggio is a TV mini-series based on the life of the Italian painter Michelangelo Merisi da Caravaggio. It opens in 1577 when the painter was 5 years old. The plague had just hit and people who were still alive were burning their household possessions.

Suor Helga is good at reading Giuseppe Moscati's moods and senses something is wrong. Giuseppe knows Elena is suffering on his account but at the same time, he can't help being dedicated to his patients over everything else. He writes Elena a letter and takes it to her house.

The RAI producers are worried about how the show is being received on the outside. They soon get some answers. Manzi is also worried, not so much about the show, but about his position as a teacher.

Camilla is interviewed by the police, and Mr. Rigas, the man she argued with in line for the bus, comes too. Renzo, who is also present, can't understand why Camilla is so profoundly affected by the event.

Imma finds out she was right about the "accident" being a homicide and goes with Calogiuri to see the architect's ex-wife and son. Calogiuri gives Imma some news she hadn't heard about.

Romano goes home expecting to see Giorgia, but she's not there. Di Nardo has her parents to deal with, but also gets an interesting text while sitting in front of the TV. The next morning, Ramaglia's daughter is trying to identify the person who had argued with her father before his death.

Elena tries to keep Luigi from getting too depressed about his situation. He then gets a taste of what his roommates had been telling him about the friar.

Giuseppe goes to see Giorgio in his fancy doctor's office, hoping to convince him to see Cloe. It's clear Giorgio has chosen the career path of least resistance, and seems more interested in fine art and fine cigars, than in treating patients who need it.

Manzi comes up with a creative way to introduce a letter that isn't technically in the Italian alphabet. Now, Manzi is famous and gets a lot of attention even when walking in the park with Ida. She feels a bit left out.

Camilla is teaching her class, but is having trouble masking her distress over her friend. She goes to the police station where the officers have some questions for her.

Imma talks to her old friend, Don Mariano, and he shows her the model of the deceased architect's pet project, never completed. Then, along with Calogiuri, Imma goes to the morgue where she is not welcome. Calogiuri's eye proves to be invaluable.

Lojacono and Di Nardo go to talk to Doctor Martone in Forensics. Di Nardo appears to know quite a bit about weapons. Back at headquarters, Romano and Aragona report to the Chief about what they found out from the prison director.

Amed is worried that the replacement chaplain will come and start talking, and never stop. He'll "press play" and tell stories ad nauseam. But on the good side, Luigi's fever is going down, even though he doesn't feel great.

Elena tries to convince her father that Giuseppe will change after they get married. He remains very skeptical. Giuseppe is spoon-feeding Cloe to give her some nourishment, meanwhile telling her how he decided to become a doctor.

After the first episode of Non è mai troppo tardi, Alberto gets some frank criticism from some of the people he cares about most: Ricotta, and his elementary school class. At RAI headquarters, some concerns have come up related to Alberto's duties as an elementary school teacher.