We meet the very chaotic Martini family at the beginning of a new season of Un medico in Famiglia (A Doctor in the Family). Some things have changed, and some haven't.

Despite the lasagna made by Cettina, everyone in the Martini family is pretty blue about Lele being gone, so they sit around in the living room. Then Annuccia decides she wants to watch a video.

The Martini family is gathered for breakfast, and we learn a bit about the individual family members. There's plenty of chaos, however, and it's a bit much for Grandpa Libero to wrap his head around. At the hospital, where Lele has vacated his office, the staff is waiting for their new boss.

Maria and Rebecca go to the university for the first time. At Lele's old work place, there is a new director. She is going to take some getting used to.

Rebecca is wandering around the campus, where she runs into someone who has his degree in medicine already. She is then joined by Maria. At the health center, the staff meets the new family doctor.

Maria visits the health center where her father used to work, and chats with the staff members she considers to be practically family. At home, there's a visit from Fausto, a friend of the family.

Little Lele, all of a sudden, feels ill. Libero, knowing he had been distracted by talking to Fausto, goes into panic mode. Maria keeps her calm and calls the doctor at the health center to find out what to do.

Grandma Enrica goes to see Libero and her grandchildren. But who knew what she would propose? Libero almost has another heart attack, and has to think fast.

Among the staff at the health center, there is gossip circulating about Doctor Zanin's past job in Milan. Zanin then has a meeting with the new director.

In the Martini household, the news leaks that Mariano will be coming to stay — another headache for Grandpa Libero, who wonders, "How did this happen?" As you watch, be on the lookout for the saying: campa cavallo. Marika explains this expression in a video lesson.

Doctor Zanin begins to be appreciated at work. Maria has a lot of studying to do but is a bit distracted. Then she gets a big surprise right in front of her house.

Guido spends his first night at the Martini residence. Cettina pulls out all the stops to impress him with a special breakfast, but not everyone in the family feels the same way.

Guido Zanin is having a hard time getting out of the house to go to work. He is definitely the center of attention for everyone, and for one person in particular...

Day two for Guido at the Health Center. It doesn't start well. Meanwhile, Grandpa Libero has his hands full at home with Lele Ju and a visit from Fausto.

Guido goes to see an old widow, who isn't a willing patient. Maria shows up at the Health Center as planned.

Grandpa Libero goes over to the university with Fausto, looking for Alberto. Maria doesn't show up at school to pick up Annuccia, and so Annuccia starts walking home by herself. Nowadays kids would never be allowed to leave school unattended.

Grandpa Libero is having a rough day with his family. Ciccio is zoned out playing video games. Alberto comes home talking about his exam, and Maria comes home without Annuccia.

Guido goes over and beyond the requirements for a housecall. Meanwhile, Cettina is bringing out the "good silver" again to impress the doctor from the big city.

Liberto wants to tell Nilde about Alberto but holds his tongue because she has her own problems. Later, with help from Fausto and Lele Ju, Libero is able to find out some more details about the exams.

Ciccio goes out with his un-named friend and we discover what the pupo (kid, puppet, baby) is. At home, Maria is studying with Rebecca, but having a hard time concentrating. When Guido finally walks in the door, there is a little misunderstanding.

Cettina helps Guido get his room in order, and discovers that an assumption she had made about him was false. Grandpa Libero has to go and confront Alberto about his absence from the university.

Alberto and his grandfather have a heart-to-heart talk about what has transpired. The conversation turns to Ciccio, who hasn't come home yet.

Grandpa Libero's bad day just got worse and he is almost at the end of his rope, overwhelmed with responsibility. Maria realizes she has to do more to help out in the family.

At the health center, Mariano is complaining about house calls, and meanwhile, Guido walks in from a house call, himself. He also shows up at home for lunch, unexpectedly. And then, Enrica shows up, as well.