Cettina helps Guido get his room in order, and discovers that an assumption she had made about him was false. Grandpa Libero has to go and confront Alberto about his absence from the university.

Alberto and his grandfather have a heart-to-heart talk about what has transpired. The conversation turns to Ciccio, who hasn't come home yet.

Grandpa Libero's bad day just got worse and he is almost at the end of his rope, overwhelmed with responsibility. Maria realizes she has to do more to help out in the family.

At the health center, Mariano is complaining about house calls, and meanwhile, Guido walks in from a house call, himself. He also shows up at home for lunch, unexpectedly. And then, Enrica shows up, as well.

Grandma Enrica is not there to rant about Doctor Zanin's presence in the household. Instead, she has a worrying incident to report, regarding Ciccio. Guido gets involved.

Guido manages to catch up with Ciccio on the train. Ciccio doesn't want to talk, but Guido talks about when he was Ciccio's age and engages him. Back home, everyone is on tenterhooks, hoping Ciccio will come back.

Neither Guido nor Nonno Libero can sleep, so they both gravitate to the kitchen. They start getting comfortable with each other, and one way to do that is dare del tu (to use the familiar form of address).

Now that they have broken the ice, Nonno Libero and Guido get down to talking about important things. Maria and Annuccia spy on them from the stairwell.

Lele Ju isn't feeling well and Guido offers to help. Grandma is observing Maria and Guido with suspicion. Grandpa Libero wants to tell Guido a long story, but it might not be the best moment.

We learn a bit more about Alberto's personal life, as some friends come to see him. Grandpa Libero finally gets to tell his story to Guido, and Annuccia has some pointed questions for her grandma.

Guido is at work and finds himself treating an interesting patient. Grandpa Libero is starting a vegetable garden, and Grandma Enrica shows up.

Libero and Enrica don't see eye to eye, but in addition to that, Enrica makes allusions she doesn't fully explain, and it leads to more incomprehension. Maria takes Lele Junior to the health center and Guido examines him.

Alberto's girlfriend, Gemma, goes to his house with the pretext of a broken cell phone. Guido and Marcello meet up in the morning at a coffee bar and the subject of acting comes up. They have very different memories of a play they were in as kids.

Gemma goes to talk to Adriano about her frustrations with Alberto. Guido has some news to share with Maria about Lele Ju.

Guido tries to talk to the Martini family about Lele Ju's intolerance, but Enrica dominates the conversation and doesn't hide her mistrust of Guido.