Some years have passed, and Michele's widowed mother has had some difficult decisions to make regarding her children. One of these is to send 12-year-old Michele to Milan to be an apprentice at the workshop of the well-known artist, Simone Peterzano. Michele has no desire to leave home and family.

Luigi spends the night tossing and turning. In the morning, a nurse comes to get him for the CT scan, but then he has to wait and wait.

After a night of intimacy, Ugo and Nora seem to have differing ideas about what it meant. Meanwhile, Iside and Dino are already basking in what they think is the aftermath.

Lojacono meets his friend Paolo for dinner and they talk about the case in which Lojacono had been falsely accused. The next day, Bukhar is questioned at headquarters.

Imma is furious about what she reads in the paper, but her boss tells her to calm down and wait for the trial. She also has to deal with a new police officer with a strong personality, but who is also quick-witted.

Camilla has to go down to the Carabinieri (police) headquarters. She tries to call Gaetano, to no avail. At the police station, she runs into the administrator of Dora's villa.

On the last day of school, Manzi goes to say goodbye to his pupils, who have taken the exam for their elementary school diplomas. He has written each of them a letter about how far they have come together and urging them never to give up. Outside the school, the principal wonders who all those people are, coming towards the school.

Giuseppe, Cloe, and Nina have a relaxing moment together at home, but then a letter arrives for Giuseppe that challenges the lighthearted atmosphere they had created.

Michele has a rough time of it in Master Simone's workshop. It's clear, however, that he has talent. A Knight of Malta comes into the workshop to have a look.

When Luigi finds out he could actually have had some water before his CT scan, he is totally demoralized. He talks about the different kinds of patients to be found in any hospital.

Nora manages to talk to Roberto for a moment to make sure he goes ahead with the divorce. She meets some potential new clients. Ugo is oblivious to these events and is busy buying flowers for Nora.

The team hears about a new homicide that likely is connected to the first one, so they have to go back to square one, more or less. The forensics expert wonders why Di Nardo doesn't answer her text messages.

Matarazzo and Calagiuri hit a dead end in their first encounter at the University of Bari. Imma finally gets to consult the files associated with Bruno's disappearance fifteen years prior. Diana asks her for a favor she shouldn't have.

As she comes out of the police station, Camilla meets up with the "indestructible" guy who had been following her and Dora. He gives her some information, but she is busy calling Gaetano for help and makes him tell her where he is. Both she and the "indestructible" go to that address.

Non è mai troppo tardi (it's never too late) was a huge success, also in many other countries. Along with youngsters who attended school, older folks managed to learn to read and write, and to get their elementary school certificates, thanks to the TV show.