Elena seems charmed by the orphans and Giuseppe explains to her that love has many pathways. At home, it becomes clear that Nina and Giuseppe have grave financial difficulties. He won't give up seeing patients, but comes up with an idea.

Michele gives one of his works to the girl in the carriage. She is Beatrice Cenci and is chained to her seat. Later, Michele is seriously wounded while loading a piece of art onto a horse-drawn cart.

Elena explains her health problem to Giuseppe and they also clarify some personal things. Giuseppe then takes her to a special place in the city.

After a night of drinking and brawling, Michele is finishing a painting outside the workshop. Baron Cenci shows up and likes what he sees on the easel. The Baron's daughter is in the carriage and exchanges a few words with Michele.

Margherita left a legacy of progress, both scientific and social. Perhaps she is still looking down on us, since an asteroid was named after her: 8558 Hack.

Giuseppe's colleagues want to get Giuseppe away from the hospital because he makes too much "trouble." Giorgio has a suggestion for that.

Caravaggio meets Onorio Longhi, Italian architect and poet, and a bit of a bohemian. Longhi takes him to meet his friend Cesare D'Arpino, who is looking for assistants in his workshop.

Even though Aldo and Margherita were very different in many ways, they came together in their skepticism. Towards the end of her life, Margherita couldn't move around much, but her brain never stopped going.

Arcangelo and Sister Helga don't like each other much, but they have to work together to save the patient. At home, at lunch, Giuseppe has a strange feeling and rushes off.

Caravaggio falls ill and makes the acquaintance of Mario Minniti who becomes a friend to him. He takes him to the hospital of the church of Santa Maria della Consolazione in Rome.

In this segment, Margherita talks about her choice not to have children and also discusses her position regarding God. She can't prove he exists nor can she prove he doesn't.

When Moscati arrives home, he has a huge surprise waiting for him: an endless stream of poor people. At the hospital, Sister Helga catches Arcangelo with a nurse and is furious.

Once in Rome, Caravaggio looks for work in the studios of 2 Italian painters who were well-known at the time. Nobody seems very interested in his work.

We discover that Margherita Hack was a devoted fan of the long-running TV series, Un posto al sole [a place in the sun]. She explains why. Francesca goes back to Trieste and meets up with Eda who talks about having lived in the same house with Margherita Hack.

In the piazza, Giuseppe discusses the war with some colleagues. He then runs into an old acquaintance. Later, in the lab, he talks about science and faith with his professor friend.