Michele goes back home after his mother dies and there, he spends some time with his childhood friend, Costanza Colonna. He tells her about his plans to go to Rome, the artistic center of the universe.

As he had promised Cloe, Giuseppe continues to look for her little boy, with little success. Some children he treats aren't really ill, they're just not getting enough to eat. Italy enters the war. Some doctors go to the front, others stay behind.

Michele manages to find a home for his painting, and receives something in exchange. Still at Maestro Simone's workshop, he grows up into a man and ends up trying to defend a young apprentice from being abused as he had been.

As her condition worsens, Cloe tells Giuseppe about the child she had abandoned, and makes him promise to find him.

Michele has a rough time of it in Master Simone's workshop. It's clear, however, that he has talent. A Knight of Malta comes into the workshop to have a look.

Giuseppe, Cloe, and Nina have a relaxing moment together at home, but then a letter arrives for Giuseppe that challenges the lighthearted atmosphere they had created.

Some years have passed, and Michele's widowed mother has had some difficult decisions to make regarding her children. One of these is to send 12-year-old Michele to Milan to be an apprentice at the workshop of the well-known artist, Simone Peterzano. Michele has no desire to leave home and family.

Nina goes back home to get some of her things and finds Cloe. She doesn't hide her resentment, but the two women end up having a conversation. Elena is clearly stufa (fed up) with Giuseppe never having time for her and she takes action.

Caravaggio is a TV mini-series based on the life of the Italian painter Michelangelo Merisi da Caravaggio. It opens in 1577 when the painter was 5 years old. The plague had just hit and people who were still alive were burning their household possessions.

Suor Helga is good at reading Giuseppe Moscati's moods and senses something is wrong. Giuseppe knows Elena is suffering on his account but at the same time, he can't help being dedicated to his patients over everything else. He writes Elena a letter and takes it to her house.

Giuseppe goes to see Giorgio in his fancy doctor's office, hoping to convince him to see Cloe. It's clear Giorgio has chosen the career path of least resistance, and seems more interested in fine art and fine cigars, than in treating patients who need it.

Elena tries to convince her father that Giuseppe will change after they get married. He remains very skeptical. Giuseppe is spoon-feeding Cloe to give her some nourishment, meanwhile telling her how he decided to become a doctor.

Cloe really does not want to stay in the hospital and Giuseppe finds a solution, but not everyone is thrilled about it.

Giuseppe would like to spend more time with Elena, but at the moment there is too much to do at the hospital. A woman brings a baby to the door of a church to leave it, but she is suddenly taken ill and falls to the ground.

Moscati tries to calm the crowd of people and help them understand that it isn't necessary to burn all their household belongings, and that cholera is transmitted through their drinking water. He promises to help treat them as Elena watches the scene from afar.