Suor Helga is good at reading Giuseppe Moscati's moods and senses something is wrong. Giuseppe knows Elena is suffering on his account but at the same time, he can't help being dedicated to his patients over everything else. He writes Elena a letter and takes it to her house.

Nina goes back home to get some of her things and finds Cloe. She doesn't hide her resentment, but the two women end up having a conversation. Elena is clearly stufa (fed up) with Giuseppe never having time for her and she takes action.

Giuseppe, Cloe, and Nina have a relaxing moment together at home, but then a letter arrives for Giuseppe that challenges the lighthearted atmosphere they had created.

As her condition worsens, Cloe tells Giuseppe about the child she had abandoned, and makes him promise to find him.

As he had promised Cloe, Giuseppe continues to look for her little boy, with little success. Some children he treats aren't really ill, they're just not getting enough to eat. Italy enters the war. Some doctors go to the front, others stay behind.

In the piazza, Giuseppe discusses the war with some colleagues. He then runs into an old acquaintance. Later, in the lab, he talks about science and faith with his professor friend.

When Moscati arrives home, he has a huge surprise waiting for him: an endless stream of poor people. At the hospital, Sister Helga catches Arcangelo with a nurse and is furious.

Arcangelo and Sister Helga don't like each other much, but they have to work together to save the patient. At home, at lunch, Giuseppe has a strange feeling and rushes off.

Giuseppe's colleagues want to get Giuseppe away from the hospital because he makes too much "trouble." Giorgio has a suggestion for that.

Elena explains her health problem to Giuseppe and they also clarify some personal things. Giuseppe then takes her to a special place in the city.

Elena seems charmed by the orphans and Giuseppe explains to her that love has many pathways. At home, it becomes clear that Nina and Giuseppe have grave financial difficulties. He won't give up seeing patients, but comes up with an idea.

Pasquale is a bit heavy-handed in his attempt to manage the collecting of money from the more well-to-do patients and Giuseppe has to step in. He and Nina sell off many of their possessions and Nina has a hard time of it. At the end of a long day, Giuseppe gets a surprise visit

Elena goes to see Giuseppe together with little Antonio. She notices right away that the apartment is empty. At the hospital, one of Mussolini's federal agents is visiting and gives Moscati some troubling news.

Giuseppe goes to see Giorgio to see if he has the power to save the hospital from the new "reforms," but Giorgio has other priorities and rebuffs him.

Giuseppe's health is failing, but he won't accept Arcangelo and Nina's advice to get some rest. He seems to be well aware of his true condition and writes a letter to his loved ones. Elena brings Antonio home.