A song about pain and heartbreak serves as background to the students who receive news of maestro Marioni's absence, due to a minor accident. The suspension of orchestra rehearsals generates different reactions among the young people, between relief, expectations for an upcoming concert and reflections on shared work.

Anna and Camilla enter Quantunque's apartment to understand why he hasn't been to the restaurant anymore; the only suspicious element is a suitcase locked with a combination. Meanwhile, at home, Renzo appears more serene after talking with his mother-in-law and attempts a reconciliation by preparing dinner.

Rosaria appears very impressed by Alex's new house and, between one compliment and another, updates her partner on the latest developments in the investigation. Meanwhile Lojacono goes to the restaurant to see Letizia, who welcomes him by offering a rich and inviting selection of typical Neapolitan dishes.

Rosario is troubled and, returning home, confides to his foster parents that he will meet his mother in his own way, alone. Meanwhile, Sofia and her brother exchange sharp remarks, while Marioni relives memories from the past, and a sudden bicycle accident transforms a quiet evening into a moment of great apprehension.

Anna is worried about Quantunque and asks Camilla to accompany her to his house to understand how he is, since he didn't come to the restaurant. Meanwhile, Torre and Piccolo enter Torrielli's apartment, finding it completely turned upside down: no clear clues emerge, except for elements that suggest an ambiguous professionalism.

Between interrogations, conflicting leads and multiplying suspicions, secrets emerge linked to the victim and their private life. Meanwhile Romano faces the weight of his own guilt and the violence he committed but is called back to a sense of responsibility by the group.

Through song, Matteo, rejected by Barbara, who chooses to remain just a friend, expresses his pain. Sofia's unconfessed feelings also emerge, as she loves Matteo in silence.

Commissioner Berardi investigates the disappearance of Mrs. Torrielli and, during an inspection, interrogates the widower Ventruti. In an informal setting, over coffee, an important detail emerges: Flora's new address.

Mrs. Nubila retraces what she knows about Lara, the young woman welcomed with almost filial affection into her family. However, the fragile balance of her life is shattered by her husband's sudden return. Di Nardo and Lojacono reveal to her an aspect of Lara's story that the woman was unaware of.

The group gets together for an evening among friends, marked however by some absences. Between relationships that are ending and unexpected revelations, the group still tries to stay united. A final toast celebrates a friendship that endures, despite everything.

Camilla introduces a reflection on couple relationships drawing inspiration from literary examples, to analyze the theme of women who are socially and economically stronger than men. Meanwhile, Torre and Berardi conduct a neighborhood investigation that leads to gossip and everyday banality, between soap operas and moral judgments.

Ottavia and Romano speak with Senatore who tells about his ambiguous relationship with Lara, described as an honest, reserved woman full of grace. After rejecting his advances, Lara decides to leave suddenly and when he is told that she was pregnant, the man appears genuinely surprised.

Marioni interrupts a lesson by his colleague Guido and harshly confronts Nathan, ordering him to show up for rehearsals with the others. The tensions center around Sara, causing conflicts to explode in the group and bringing personal vulnerabilities to light.

Gaetano and Camilla discuss their relationship difficulties, including jealousy and advice on how to communicate better. The conversation intertwines with investigative work when Camilla asks for more information regarding the recent murder.

Domenico postpones his appointment with Gloria, who is hurt and fears something is wrong. Matteo tries to make peace with his uncle to confess that he has invited some friends to dinner, while Sara finds herself dealing with a disappointment that puts her to an emotional test.