We discover where Alberto's favorite T-shirt is hiding. Lele is looking for any excuse not to go to Irene's house for dinner, and his parents-in-law show up in time to wonder where he is going and give him a rough time.

Lele goes to Irene's house, but neither he nor Irene is really at ease. Meanwhile, the Martini's next-door neighbor stops by to complain about the dog.

Lele and Irene aren't exactly at ease as they eat their fish dinner. Giulio has the audacity of calling Lele to find out how things are going. Back at home, Maria and Ciccio wonder about their father remarrying and what that would be like.

Lele and Irene have some awkward moments at dinner and afterwards. Giulio is back at the house with Alice, wondering how the evening went. He can't help saying inappropriate things and Alice finally gets fed up with him.

Giulio shows up early to the house to find out how things went between Lele and Irene. Lele gets teased by just about everyone about his "wild night." At the clinic, the woman who had accused Mariano of molesting her shows up again. This time it is Lele who has to deal with her.

Lele gets a surprise visit at work. Later, he discusses it with Alice. Mariano comes back to work with some baccalà, a sort of salted codfish that lots of people love, but lots of people hate.

Ciccio and Libero are watching TV when Alberto comes to ask about his tee shirt, and the doorbell rings. It's someone about the dog. Lele goes to Irene's place to talk to her.

It's dinner time in the Martini household. Ciccio is finishing his homework, Alberto is going to play soccer with some friends, Maria apologizes to her father, and Giulio shows up to make trouble, as usual.

We meet the very chaotic Martini family at the beginning of a new season of Un medico in Famiglia (A Doctor in the Family). Some things have changed, and some haven't.

Despite the lasagna made by Cettina, everyone in the Martini family is pretty blue about Lele being gone, so they sit around in the living room. Then Annuccia decides she wants to watch a video.

The Martini family is gathered for breakfast, and we learn a bit about the individual family members. There's plenty of chaos, however, and it's a bit much for Grandpa Libero to wrap his head around. At the hospital, where Lele has vacated his office, the staff is waiting for their new boss.

Maria and Rebecca go to the university for the first time. At Lele's old work place, there is a new director. She is going to take some getting used to.

Rebecca is wandering around the campus, where she runs into someone who has his degree in medicine already. She is then joined by Maria. At the health center, the staff meets the new family doctor.

Maria visits the health center where her father used to work, and chats with the staff members she considers to be practically family. At home, there's a visit from Fausto, a friend of the family.

Little Lele, all of a sudden, feels ill. Libero, knowing he had been distracted by talking to Fausto, goes into panic mode. Maria keeps her calm and calls the doctor at the health center to find out what to do.