Caravaggio meets Onorio Longhi, Italian architect and poet, and a bit of a bohemian. Longhi takes him to meet his friend Cesare D'Arpino, who is looking for assistants in his workshop.

Even though Aldo and Margherita were very different in many ways, they came together in their skepticism. Towards the end of her life, Margherita couldn't move around much, but her brain never stopped going.

Caravaggio falls ill and makes the acquaintance of Mario Minniti who becomes a friend to him. He takes him to the hospital of the church of Santa Maria della Consolazione in Rome.

In this segment, Margherita talks about her choice not to have children and also discusses her position regarding God. She can't prove he exists nor can she prove he doesn't.

Once in Rome, Caravaggio looks for work in the studios of 2 Italian painters who were well-known at the time. Nobody seems very interested in his work.

We discover that Margherita Hack was a devoted fan of the long-running TV series, Un posto al sole [a place in the sun]. She explains why. Francesca goes back to Trieste and meets up with Eda who talks about having lived in the same house with Margherita Hack.

In the piazza, Giuseppe discusses the war with some colleagues. He then runs into an old acquaintance. Later, in the lab, he talks about science and faith with his professor friend.

Michele goes back home after his mother dies and there, he spends some time with his childhood friend, Costanza Colonna. He tells her about his plans to go to Rome, the artistic center of the universe.

Margherita Hack spent some time in politics and was also an entrepreneur at times. But she had a lot of fun, too. On the panel with Camilleri, the author of the Montalbano stories, they all come out (in unison) with the famous introduction Montalbano sono (Montalbano, I am). Putting the verb at the end is typical of Sicily, where the story takes place. Otherwise, it would be Sono Montalbano (I'm Montalbano) or, on the phone, "This is Montalbano."

As he had promised Cloe, Giuseppe continues to look for her little boy, with little success. Some children he treats aren't really ill, they're just not getting enough to eat. Italy enters the war. Some doctors go to the front, others stay behind.

Michele manages to find a home for his painting, and receives something in exchange. Still at Maestro Simone's workshop, he grows up into a man and ends up trying to defend a young apprentice from being abused as he had been.

Margherita Hack was a scientist and communicator, but she also expressed her opinions about attualità (current events). Part of this segment features a panel discussion she held with author Andrea Camilleri, best known for his novels about Inspector Montalbano that became a popular TV series.

Michele has a rough time of it in Master Simone's workshop. It's clear, however, that he has talent. A Knight of Malta comes into the workshop to have a look.

Margherita Hack's talents lay not only in her greatness as a scientist, but also in her remarkable ability to communicate with the general public, and especially young people. She rendered complicated information comprehensible and interesting, using clear and simple examples.

Giuseppe, Cloe, and Nina have a relaxing moment together at home, but then a letter arrives for Giuseppe that challenges the lighthearted atmosphere they had created.