This documentary about the life of Vittorio De Sica, Italian actor and film director, is narrated by Marco Paolini. We begin during the occupation by the Nazis. Vittorio is in Rome shooting a film.

Moscati and his assistants do what they can, but they discover that the government has a different view of the situation.

Not only did she win a Nobel prize; in her own country, she was appointed as a Senator for life, a great honor. But she took that job seriously and participated actively and with integrity. Not everyone appreciated that.

Elena is at the fancy dinner, and is worried about Giuseppe, but at the same time, she is fascinated by the after-dinner entertainment. Giorgio is taking advantage of Giuseppe's absence. Meanwhile, Giuseppe is working against the clock, realizing that his patient, from one of the poorest and most dangerous neighborhoods of Naples, has a terrible disease.

After winning the Nobel prize, Rita Levi-Montalcini was not as shy as she had been prior to that moment. Because she stood out as a woman in a "man's world," she was able to use her unique position to make her mark, not only in the science world, but in society.

After being left by the taxi driver, Giuseppe goes in search of the Esposito home. The taxi driver was right about the danger. Meanwhile, Giorgio shows up at the dinner and greets Elena and her father.

Rita Levi Montalcini doesn't feel like she made any sacrifices in her life, including not having a family. She had a clear vision of what she wanted out of life, and she followed it.

Giorgio is getting settled in his new office and gets an unexpected and unwelcome visitor. Giuseppe has a big evening ahead of him with Elena and her father, but he gets some news he has to take care of and is delayed.

Sister Helga and Moscati give the patient a bath and talk about how medicine is nothing without love. Moscati has some unorthodox teaching methods, as well as some novel "therapy" for his patients.

The formal, ceremonious aspect of the Nobel Prize awards was not what Rita Levi-Montalcini was used to, but she used that recognition to her advantage. Winning the Nobel Prize wasn't necessarily the high point in her career.

Moscati discovers what Aniello died of and feels profoundly aggrieved and powerless. He seems to have doubts about his role as a doctor.

Because of the racial laws in Italy during the period of Fascism, many Jews left the country, including Rita Levi Montalcini. In Italy she wasn't allowed to work or publish papers, but somehow, she found a way to keep going.

Moscati can't find Aniello in the hospital and discovers he had run off. Moscati goes out looking for him.

Rita Levi Montalcini was a strong proponent of education and instruction as the means to gain freedom. She was also an example of it. This segment describes a visit to women in prison, and the obstacles Montalcini had to face, as a woman and as a Jew, during the Nazi-Fascist regime.

Giorgio goes to see Cloe perform, but afterwards, he makes an important decision. Giuseppe finally finds Aniello, who is not doing well at all.