Caravaggio is a TV mini-series based on the life of the Italian painter Michelangelo Merisi da Caravaggio. It opens in 1577 when the painter was 5 years old. The plague had just hit and people who were still alive were burning their household possessions.

This segment recounts how Aldo De Rosa and Margherita met in a park in Florence as kids and later married. Aldo supported her in her scientific work throughout their marriage, which lasted over seventy years.

Suor Helga is good at reading Giuseppe Moscati's moods and senses something is wrong. Giuseppe knows Elena is suffering on his account but at the same time, he can't help being dedicated to his patients over everything else. He writes Elena a letter and takes it to her house.

The general hands De Sica a letter from Goebbels himself but since De Sica can't read German, it is translated for him ad alta voce (out loud). It's an invitation to Venice, which De Sica does not want to accept.

Although as an athlete, Margherita did make some compromises she felt she had to during the decades of Italian Fascism, she also took a stand against it, risking expulsion from school.

Giuseppe goes to see Giorgio in his fancy doctor's office, hoping to convince him to see Cloe. It's clear Giorgio has chosen the career path of least resistance, and seems more interested in fine art and fine cigars, than in treating patients who need it.

Actors, including Alberto Sordi, who were performing at the Quattro Fontane (four fountains) theater on the fateful day of 23 March 1944 are in danger of being caught by the Germans. During the filming of his movie, De Sica leaves the safety of the basilica just once and is caught and questioned by a Nazi General about why the film is taking so long to be shot.

Perhaps not everyone knows that Margherita Hack as a girl was quite the athlete. Her sport was track and field. She also had a passion for cycling and rode her bike well into her seventies.

Elena tries to convince her father that Giuseppe will change after they get married. He remains very skeptical. Giuseppe is spoon-feeding Cloe to give her some nourishment, meanwhile telling her how he decided to become a doctor.

During the filming of Heaven's Gate, there were some dicey moments where De Sica had to deal with the German troops and needed all his wits about him. At the same time his crew was cooped up in the basilica and didn't always behave as they should — in fact, tutt'altro (anything but). The narrator also mentions an anecdotal story Fellini told about his experience with the Germans.

Margherita was much more interested in substance and knowledge than in material things, including physical appearance, and this became her brand, in a certain sense. That didn't keep people from loving and respecting her, although there were some occasional incidents, a few of which are recounted by people who knew her.

Cloe really does not want to stay in the hospital and Giuseppe finds a solution, but not everyone is thrilled about it.

To recreate the environment of the San Loreto church, the Basilica of St Paul's Outside the Walls was used for the final scene of the film. The crew was accustomed to working in a non-religious setting where they could do as they liked, so it was a full-time job trying to keep their bad habits (such as smoking) in check so they wouldn't get kicked out by their hosts.

Margherita Hack made her mark on the University of Trieste, teaching Astronomy there for almost 30 years and linking it with the Observatory. She had to use some drastic means to be recognized, however, being a woman in a man's world. But the balance changed over time, with her help, to involve many more women than before, both as students and researchers.

Giuseppe would like to spend more time with Elena, but at the moment there is too much to do at the hospital. A woman brings a baby to the door of a church to leave it, but she is suddenly taken ill and falls to the ground.